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A review of metallic nanoparticles : present issues and prospects focused on the preparation methods, characterization techniques, and their theranostic applications
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Abstract:
Metallic nanoparticles (MNPs) have garnered significant attention due to their
ability to improve the therapeutic index of medications by reducing multidrug
resistance and effectively delivering therapeutic agents through active targeting.
In addition to drug delivery, MNPs have several medical applications, including
in vitro and in vivo diagnostics, and they improve the biocompatibility of materials
and nutraceuticals. MNPs have several advantages in drug delivery systems and
genetic manipulation, such as improved stability and half-life in circulation,
passive or active targeting into the desired target selective tissue, and gene
manipulation by delivering genetic materials. The main goal of this review is to
provide current information on the present issues and prospects of MNPs in drug
and gene delivery systems. The current study focused on MNP preparation
methods and their characterization by different techniques, their applications
to targeted delivery, non-viral vectors in genetic manipulation, and challenges in
clinical trial translation.
Description:
Date:
2024
Authors:
Shahalaei, Mona
Azad, Abul Kalam
Wan Mohd Azizi Wan Sulaiman
Derakhshani, Atefeh
Mofakham, Elmira Banaee
Mallandrich, Mireia
Kumarasamy, Vinoth
Subramaniyan, Vetriselvan
Publisher:
Frontiers
