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A dataset of microstructure features of electro-hydrodynamic assisted 5-fluorouracil-grafted alginate microbeads and physicochemical properties for effective colon targeted carriers drug delivery

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dc.contributor.authorAzad, Abul Kalam
dc.contributor.authorWan Mohd Azizi Wan Sulaiman
dc.contributor.authorAlmoustafa, Hassan
dc.contributor.authorMohamad Dayoob
dc.contributor.authorKumarasamy, Vinoth
dc.contributor.authorSubramaniyan, Vetriselvan
dc.contributor.authorAlshehri, Jamilah M.
dc.contributor.authorKhan, Azmat Ali
dc.date.accessioned2026-10-16T06:39:00Z
dc.date.available2026-10-16T06:39:00Z
dc.date.issued2024
dc.description.abstract5-Fluorouracil (5-FU) has been the primary drug used in chemotherapy for colorectal carcinoma, and localizing the drug would be effective in avoiding its side effects and improving therapeutic outcomes. One approach to achieve this is by encapsulating the drug in microbeads. Alginate microbeads, in particular, exhibit promising pH-sensitive properties, making them an attractive option for colon targeting. Thus, the main aim of this study is to formulate and characterize 5-FU-encapsulated alginate microbeads as a pH-sensitive drug delivery system for controlled release in the gastrointestinal tract. In this study, the alginate microbeads encapsulating 5-FU was manufactured using electrospray methods. This method offers the advantages of promoting the formulation of uniformly small-sized mi- crobeads with improved performance in terms of swelling and diffusion rates. The size and shape of the 5-FU mi- crobeads are 394.23 ±3.077 μm and have a spherical fac- tor of 0.026 ±0.022, respectively, which are considered ac- ceptable and indicative of a spherical shape. The microbeads’ encapsulation efficiency was found to be 69.65 ±0.18%, which is considered high in comparison to other literature. The attenuated total reflectance - Fourier transform infrared spectroscopy (ATR-FTIR) data confirmed the complexation of sodium alginate with calcium ions, along with the encap- sulation of 5-FU in the microbeads matrix. The 5-FU mi- crobeads displayed pH-dependent swelling, exhibiting less swelling in simulated gastric fluid (SGF) than in simulated in- testinal fluid (SIF). Additionally, the release of 5-FU from the microbeads is pH-dependent, with the cumulative percent- age drug release being higher in simulated intestinal fluid than in SGF. The data indicate that the 5-FU microbeads can be utilized for the delivery of 5-FU in colon-targeted therapy, potentially leading to improved tumor treatment.
dc.format.extent13 pages
dc.identifier.urihttps://doi.org/10.1016/j.dib.2024.110202
dc.identifier.urihttps://repository.ubd.edu.bn/handle/123456789/4734
dc.language.isoen
dc.publisherElsevier Inc.
dc.sourceData in Brief
dc.subject.lcshDrug delivery systems
dc.subject.lcshFluorouracil
dc.subject.lcshAlginates
dc.subject.lcshMicroencapsulation
dc.subject.lcshElectrohydrodynamics
dc.titleA dataset of microstructure features of electro-hydrodynamic assisted 5-fluorouracil-grafted alginate microbeads and physicochemical properties for effective colon targeted carriers drug delivery
dc.typeArticle
dspace.entity.typePublication
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